Discover RNA’s irresistible ascent from humble molecule to CRISPR star

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The most effective covid‑19 vaccines had RNA at their heart

Ezra Acayan/Getty Images

The Catalyst
Thomas R. Cech (W. W. Norton)

For 50 years, RNA was DNA’s undervalued sibling, but now it has jumped into the spotlight. This multifaceted molecule – which resembles DNA but can morph into a variety of shapes other than a double helix – brought us the most effective covid-19 vaccines and is key to CRISPR gene editing, one of the most powerful technologies in experimental biology.

Yet few of us have an in-depth understanding of the molecule and why it has suddenly become so important for…

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